NEPHROPROTECTIVE ACTIVITY OF VITEX NEGUNDO LINN BARK AGAINST CHEMICAL INDUCED TOXICITY IN EXPERIMENAL RATS

The present study shows the nephroprotective activity of methanolic extracts of Vitex negundo linn bark (VBE) against chemical induced kidney damage. Kidney damage was induced by single oral administration of 750 mg/kg of paracetamol in male wistar rats (150-200) on the 14 th day. Kidney damage was studied by assessing the biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALT), Bilirubin, total protein and enzymatic antioxidants which includes SOD, CAT, GSSH, GPx, PX, and non- enzymatic antioxidants, such as GSH. The methanolic extracts of Vitex negundo linn bark (200 mg/kg, 400 mg/kg) were orally administered to the animals once daily for 14th days. The methanolic extracts of Vitex negundo linn bark (200 mg/kg, 400 mg/kg) results in a significant reduction on biochemical parameters as well as enzymatic and non-enzymatic antioxidants when compared to the paracetamol induced kidney toxicity. The result concludes that the methanolic extract of vitex negundo linn bark (200, 400 mg/kg) has protected the kidney from paracetamol induced toxicity.