Microtubules and Tubulins as Target for Some Natural Anticancer Agents Extracted from Marines,Bacteruim, and Fungus

Microtubules are key components of cytoskeleton and they play role in maintaining cell structure ,providing platforms for intracellular transportation,forming the spindle during mitosis ,signaling cells , in cell division and mitosis.Their dynamic structures and their role in mitosis candidate them an efficient target for anticancer development. Plants ,marine organisms and microorganisms are consisted of substances which have anticancer properties.In present study ,we evaluated natural anticancer agents which are extracted from marines,fungus,and bacterium in order to define their main targets by PASS software.According to our results, Epothilone, Okadaic acid , Ixabepilone, Dictyostatin, Bryostatin, Peloruside A,and Saliniketal are as microtubule stabilizer agents and it is demonstrated Peloruside A, Epothilone ,and Bryostatin with PASS scores 0.973, 0.948,and 0.913 respectively are as the strongest microtubule stabilizer molecules. In addition , Pironetin, Discodermolide,and Rhizoxin are as tubulin antagonists agents.Therefore, Pironetin with score 0.806 releaved the highest anticancer effects via binding to tubulins among other three molecules.It is intereseting that Bryostatin, Peloruside A,and Rhizoxin exhibited high cytotoxic activity.