Self major histocompatibility complex class-II-specific regulatory CD4 T cells prevent both Th1- and Th2-mediated autoimmune diseases in the rat

Abstract It is clear that functional heterogeneity of T cells may be explained by differential cytokine production. The aim of this paper was to review evidence for ˈregulatory cellsˈ, generated after HgCl 2 -exposure. They differ from classical Th1 and Th2 cells, produce transforming growth factor-β and interleukin-10 and exert their regulatory functions in a Th1/Th2-unrestricted fashion.