Advances in molecular mechanisms of liver ischemia reperfusion injury

Ischemia reperfusion injury (IRI) represents the main cause of liver damage during surgical procedures such as hepatic resection and liver transplantation, it is an inevitable process of liver transplantation, which may lead to liver function failure and affect the postoperative short-term and long-term efficacy of liver transplant recipients. The molecular mechanisms occurring during hepatic ischemia reperfusion are largely unknown and keeping update. This review aims to summarize some significant molecular mechanisms in research progress of liver IRI. In addition, some new strategies for alleviating IRI are outlined to provide theoretical and scientific basis for clinical improvement of postoperative graft survival rate and liver transplantation curative effect. Key words: Ischemia reperfusion injury; Molecular mechanism; Liver; Liver transplantation