Protein kinase inhibitors 2-substituted pyrrole indoline.

A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from hydrogen, (C1-C4), - (CH2) RR16 and -C (O) NR8R9; R2 is selected from hydrogen, halogen, aryl and -S (O) 2NR13R14; R3 is selected from hydrogen, (C1-C4) alkoxy (C1-C4), aryl, heteroaryl, and -C (O) R15; R4 is hydrogen; R5 is selected from hydrogen and (C1-C4); R6 is -C (O) R10; R7 is selected from hydrogen, (C1-C4) and aryl; R8 and R9 are independently selected from hydrogen, alkyl and aryl; R10 is -N (R11) (CH2) n R 12 wherein n is 1, 2 or 3, R11 is hydrogen and R12 is selected from hydroxy, (C1-C4), -C (O) R15, heteroaryl and - NR13R14; R13 and R14 are independently selected from the group consisting of hydrogen. (C1-C4) alkyl, aryl and heteroaryl; or R13 and R14 may combine to form a heterocyclo group; R15 is selected from the group consisting of hydrogen, hydroxy, (C1-C4) and aryloxy; R16 is selected from hydroxy and -C (O) R15; r is 2 or 3; and wherein: alkoxy refers to O-alkyl or O-cycloalkyl; aryloxy refers to O-aryl or O-heteroaryl; heteroaryl refers to a monocyclic group or condensed ring from 5 to 12 ring atoms containing one, two or three ring heteroatoms selected from N, O or S, the remaining ring atoms C; heterocyclo group refers to a saturated cyclic radical of 3 to 8 ring atoms in which one or two ring atoms are heteroatoms selected from N, O or S (O) n where n is an integer from 0 to 2 , the remaining ring atoms C, where one or two C atoms are optionally replaced by a carbonyl group; alkyl, alkoxy and cycloalkyl are unsubstituted; aryl and heteroaryl groups are optionally substituted with one or two substituents independently selected from halo, (C1-C4), trihalo (C1-C4), hydroxy, mercapto, cyano, N-amido, mono- or di- (C1-C4 ) amino, carboxy and N-sulfonamido; the heterocycle group is optionally substituted with one or two substituents independently selected from halo, -C (C1-C4) alkyl, (C1-C4) carboxy, -C (C1-C4) ester, hydroxyl and mono- or dialkyl (C1-C4) amino.