Les tumeurs stromales gastro-intestinales : profil épidémiologique, clinique et thérapeutique au CHU de Marrakech

Stromal tumors or GIST (gastrointestinal mesenchymal tumors) are rare (1-3% of gastro-intestinal malignancies). They are a subject of controversy. We report a retrospective study of 17 cases of gastrointestinal stromal tumors confirmed histologically and immuno-histochemically, collected at the University Hospital Mohammed VI. The average age of patients was 59 years, (29-80 years). The symptoms were abdominal pain in most cases (49%), abdominal mass found in 35% of our patients and hepatomegaly in 2 cases. There were 6 cases of gastric tumors, 4 cases of mesenteric tumors, 4 cases of jejunal tumors, and 3 cases of rectal tumors. Fifteen patients were treated with complete surgical resection. A histological marker expression C KIT was present in 100% of cases. In 13 cases tumors were localized, 2 patients had locally advanced tumors immediately and 2 others had liver metastases at diagnosis. Medication with Imatinib was initiated in the tumors classified high-grade malignancy in 6 cases in adjuvant and neoadjuvant in 2 cases. On a mean of 3 years, the 3-year survival was 88% and we had 8 cases of complete remission, 3 cases of partial remission, 2 cases of tumor recurrence and 2 deaths. Hegel Vol. 3 N° 1 – 2013 37 © aln.editions