Proteins of mammalian epidermis.
1955
Epidermis is rather well suited for chemical investigations since it consists of cells derived from a single type, and this tissue is avascular and alymphatic. Histologically epidermis is quite complex since it is characterized by cells representing all stages of differentiation from the basal cells to those which have become completely cornified. The various degrees of differentiation exhibited by epidermal cells are excellent and rewarding subjects for biochemical investigation. Keratinization occurs concomitantly with differentiation ; it apparently begins in the lower layers of the epidermis, and it is completed in the protective coating of keratin (1).
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