Agents of urinary tract infections in children and their antibiotic susceptibility

Objective: We aimed to detect common micro-organisms in children with urinary tract infections in our region and to determine. empirical antibiotic options according to their antibiotic sensitivity and resistance patterns Materials and Methods: Urine culture results of children with a diagnosis of urinary tract infection between January 2005 and June 2008 in Tokat at Gaziosmanpasa University School of Medicine Department of Pediatrics inpatient and outpatient clinics were analyzed retrospectively. Results: Sixty (25%) were male and 183 (75%) were female, a total of 301 urine cultures of microorganisms isolated from 243 children were evaluated. The percentage of isola ted microorganisms were E. Coli 74.8%, Klebsiella spp. 11.3%, Enterobacter spp. 2.4%, Proteus 1% and gram-positive 5%. The most frequently isolated microorganism, E. coli, has antibiotic resistance as followed ampicillin 69.3%, trimethoprim sulfamethoxazole (TMP + SMX) 54.8% and amikacin 3.2%. The second most common microorganism Klebsiella spp has antibiotic resistance as followed ampicillin 95.2%, Tmp + sxm 40.9% and amikacin 1%. Conclusion: Over the years, the resistance to ampicillin and TMP + SMX has increased. By unnecessary, improper and irregular drug use, the development of antimicrobial resistance for different antibiotics can be expected. Choosing appropriate antibiotic with taking into consideration of offers that were in common guidelines with the regional antibiotic resistance, development of resistance to different antibiotics can be prevented.