Synthesis, characterization, DNA binding and anticancer property of mer-trichlorodimethylsulphoxide-S-(1, 10- phenanthroline) ruthenium (III)

The mer-trichloro dimethylsulphoxide-S-(1,10-phenanthroline) ruthenium (III) ((Ru(phen)(DMSO)Cl3)) complex has been synthesized. The structure has been characterized from FT-IR, 1 H NMR and UV-Vis spectroscopic data. The geometry of this complex determined by single crystal X-ray diffraction study was found to be octahedral. The binding of this complex with Calf Thymus DNA (CT-DNA) has been investigated by spectroscopic, electrochemical and electrophoresis studies. Anticancer activity of this compound studied both in vivo and in vitro against Dalton's lymphoma in mice was found to be significant.