Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus

Roberta Tancredi Francesco dos Santos,Marcelo Florencio Passos Silva,Rafael Marques-Porto,Ivo Lebrun,Luis Roberto de Camargo Gonçalves,Isabel de Fátima Correia Batista,Maria Regina Lopes Sandoval,Fernando Maurício Francis Abdalla

Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus

2020

Roberta Tancredi Francesco dos Santos
Marcelo Florencio Passos Silva
Rafael Marques-Porto
Ivo Lebrun
Luis Roberto de Camargo Gonçalves
Isabel de Fátima Correia Batista
Maria Regina Lopes Sandoval
Fernando Maurício Francis Abdalla

Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs).

Keywords:

Pharmacology
Venom
Virology
Micrurus lemniscatus
Muscarinic acetylcholine receptor
Phospholipase A2
Hippocampus
Biology
MLX
Pirenzepine
Carbachol
Inositol phosphate
Molecular biology
Muscarinic agonist
Muscarinic antagonist

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