EFFECTS OF DEXTRANATION ON THE PHARMACOKINETICS OF SHORT PEPTIDES. A PET STUDY ON MEGF

Qinghai Zhao,Vladimir Tolmachev,Jörgen Carlsson,Hans Lundqvist,Johanna Sundin,Jan-Christer Janson,Anders Sundin

EFFECTS OF DEXTRANATION ON THE PHARMACOKINETICS OF SHORT PEPTIDES. A PET STUDY ON MEGF

1999

Qinghai Zhao
Vladimir Tolmachev
Jörgen Carlsson
Hans Lundqvist
Johanna Sundin
Jan-Christer Janson
Anders Sundin

The effects of dextranation on the biodistribution of mouse epidermal growth factor (mEGF, 6 kDa) were assessed. By reductive amination, mEGF was coupled to 13 and 46 kDa dextran. The two dextranat ...

Keywords:

Epidermal growth factor
Reductive amination
Dextran
Molecular biology
Chemistry
Pharmacokinetics
Biodistribution
Cell culture
kinetic analysis
Biochemistry
rat liver

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