A combined adjuvant and carrier system for enhancing synthetic peptides immunogenicity utilising lipidic amino acids

Abstract The Lipid-Core-Peptide (LCP) system which incorporates lipidic amino acids to the polylysine system to enhance lipophilicity and membrane binding effects of a potential peptide-vaccine is an excellent means for enhancing antigenicity. Different spacer-(lipidic amino acid) n -(L-Lys) m systems were synthesised on solid phase, with a fully automated procedure, using BOC strategy.