Formulation And Evaluation Of Lincomycin HCl Gels

Lincomycin is an antibiotic active against most common gram positive and several anaerobic organisms. It has proved to be excellent for the treatment of skin conditions such as furunculosis, abscesses, carbuncles, cellulities, erysipelas, impetigo, infection burns and wounds. Gels were prepared using different gel forming agents such as carbopol-940, HPC, HPMC and PEG 6000 in different proportions. The formulations were evaluated for drug content, viscosity, pH, extrudability, homogentity, irritation test, spreadability and skin permeation studies through rat skin using kashery chein cell. Formulation F5 with carbopol 940 (1.5%) as the gel forming agents was found to be the best.