DATA MINING APPROACH FOR IN-HOSPITAL TREATMENT OUTCOME IN PATIENTS WITH ACUTE CORONARY SYNDROME PROCENA INTRAHOSPITALNOG ISHODA LEČENJA PACIJENATA SA AKUTNIM KORONARNIM SINDROMOM METODOM ISTRAŽIVANJA PODATAKA
2015
Summary Introduction. Risk stratification is nowadays crucial when esti- mating the patient's prognosis in terms of treatment outcome and it also helps in clinical decision making. Several risk assessment models have been developed to predict short-term outcomes in patients with acute coronary syndrome. This study was aimed at developing an outcome prediction model for patients with acute coronary syndrome submitted to percutaneus coronary interven- tion using data mining approach. Material and Methods. A total of 2030 patients hospitalized for acute coronary syndrome and treated with percutaneous coronary intervention from December 2008 to December 2011 were assigned to a derivation cohort. Demographic and anamnestic data, clinical characteristics on admission, biochemical analysis of blood parameters on admis- sion, and left ventricular ejection fraction formed the basis of the study. A number of machine learning algorithms available within Waikato Environment for Knowledge Discovery had been evalu- ated and the most successful was chosen. The predictive model was subsequently validated in a different population of 931 pa- tients (validation cohort), hospitalized during 2012. Results. The best prediction results were achieved using Alternating Decision Tree classifier, which was able to predict in-hospital mortality with 89% accuracy, and preserved good performance on valida- tion cohort with 87% accuracy. Alternating Decision Tree classi- fier identified a subset of 6 attributes most relevant to mortality prediction: systolic and diastolic blood pressure, heart rate, left ventricular ejection fraction, age, and troponin value. Conclusion. Data mining approach enabled the authors to develop a model capable of predicting the in-hospital outcome following percuta- neous coronary intervention. The model showed excellent sensitiv-
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