SYNTHESIS,CHARACTERIZATION, ANTI- PROSTATE CANCER DOCKING AND IDENTIFICATION OF TARGET SITE OF VARIOUS MANNICH BASES OF QUINAZOLINONES

Aim: Cancer is a serious disease that not fully defined now-a-days. The problem of cancer is the metastatis, and the unnatural proliferation of the cell. Many chemotherapeutic agents are used to treat cancer, but they failed to cure the cancer patient. They may prevent some of the portion but not totally defend against cancer. So our work devoted to design a novel chemotherapeutic agent with minimal sideeffects against prostate cancer. Methods: Various mannich bases of 2,3-dihydroquinazolin-4(1H)-ones were synthesized in a three step process. The reaction proceeds via reductive cyclization for the formation of quinazolinone nucleus. Further, mannich bases were prepared by the reaction of quinazolinone parent nucleus with various aldehydes and secondary amines. Spectral studies such as IR, NMR and Mass were carried out. Docking was performed by the employment of AutoDock version 4.0 against Androgen receptor obtained from the PDB. Results: Compounds 3d and 3e had shown good binding energy values and showed that they can act against prostate cancer. Conclusion: Compounds 3d and 3e were found to be most active when compared to other synthesized derivatives with binding energies of 8.41Kcal/mol and -8.2Kcal/mol respectively. The yield of the two compounds was also satisfactory. Binding energy values obtained were very high when compared with previous analysis as per review of literature.