Epidemiology of Human Herpesvirus Type 8 Infection in Cardiopathic Patients
2009
Problem statement: The possible contribution of viruses to vascular
pathology is still a controversial issue. Human herpesvirus type 8 (HHV-8) has
been suggested to participate to the pathogenetic events associated with atherosclerotic
lesion establishment and progression. Recently, a high incidence of infection
of HHV-8 (11%) has been verified in the island of Sardinia. The aim of this study
was to evaluate a possible relationship between the HHV-8 infection and cardiovascular
diseases in the South of Sardinia. Approach: The presence of
HHV-8 genome was detected in DNA extracted from peripheral leucocytes, by nested-PCR
and Southern blotting, in either acute or chronic cardiopathic patients (n = 180);
healthy blood donors were examined as controls (n = 108). Results: The
results demonstrated a significant increase (p = 0.035) in HHV-8 DNA isolation
from cardiopathic patients (22.8%) in comparison to healthy controls (12.0%).
Conclusion: HHV8 infection can be considered, among others, as
an additional risk factor for cardiovascular disease development, although it
was not necessarily the starting cause. More extensive studies were needed to
define the exact role of HHV-8 infection in cardiopathic patients.
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