Evaluating the morphological changes of intracranial arteries and whole-brain perfusion in undetermined isolated vertigo

Abstract Purpose To determine the morphological changes of intracranial arteries and whole-brain perfusion in undetermined isolated vertigo (UIV) patients using 320-detector row computed tomography (CT). Methods A total of 150 patients who underwent CT angiography (CTA) and CT perfusion (CTP) imaging were divided into UIV group and benign paroxysmal positional vertigo (BPPV) group. Sixty individuals with sex- and age-matched without vertigo and cerebral diseases served as the control. The morphological changes of intracranial arteries, perfusion parameters and vascular risk factors (VRFs) were analyzed, calculated and compared. Results In UIV patients, hypertension (HT), hyperlipidemia and number of VRFs ≥ 3 occurred more commonly ( P P P  = 0.014). HT and VAD associated with BAC served as risk predictors (OR: 4.081, 95%CI: 1.056;15.775, P  = 0.041 and OR: 6.284, 95%CI: 1.848; 21.365, P  = 0.003, respectively). The absolute difference in relative values of CTP parameters from cerebellum and brainstem were significantly different ( P P Conclusions On the basis of multiple VRFs, morphological changes of vertebrobasilar artery (VBA) and the unilateral hypoperfusion of the cerebellum and brainstem, that acts as a herald for IV occurrence, which should be paid cautious attention to UIV patients.