Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu

Vinod Kumar,Kamesh Ayasolla,Alok Jha,Abheepsa Mishra,Himanshu Vashistha,Xiqian Lan,Maleeha Qayyum,Sushma Chinnapaka,Richa Purohit,Joanna Mikulak,Moin A. Saleem,Ashwani Malhotra,Karl Skorecki,Pravin C. Singhal

Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu

2019

Vinod Kumar
Kamesh Ayasolla
Alok Jha
Abheepsa Mishra
Himanshu Vashistha
Xiqian Lan
Maleeha Qayyum
Sushma Chinnapaka
Richa Purohit
Joanna Mikulak
Moin A. Saleem
Ashwani Malhotra
Karl Skorecki
Pravin C. Singhal

We hypothesized that a functional APOL1-miR193a axis (inverse relationship) preserves, but disruption alters the podocyte molecular phenotype through the modulation of autophagy flux. Podocytes-exp...

Keywords:

Phenotype
Blockade
Molecular biology
Podocyte
Autophagy
Cell biology
Biology
Apolipoprotein B
molecular phenotype
Apolipoprotein L1

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