Levodropropizine clathrate dispersible tablet and preparation method thereof

2015 
The invention provides a levodropropizine clathrate dispersible tablet and a preparation method thereof. The invention, which processes levodropropizine as a clathrate firstly and then prepares a dispersible tablet from the levodropropizine clathrate, integrates inclusion and dispersion technologies to take the advantages of the two aspects. The levodropropizine is included by virtue of cyclodextrin and the dispersible tablet is prepared in coordination with accessories of special type and dosage, so as to solve a problem of bitterness and to take an effect of masking bitter taste; and the preparation effect of the dispersible tablet is significantly enhanced and a degradation effect is accelerated. The levodropropizine dispersible tablet prepared according to the formula can be completely released within a short time; the dispersible tablet is reasonable in formula, and is capable of masking the bitter taste, improving the mouthfeel of the levodropropizine dispersible tablet taken by patients and enhancing drug compliance; and the preparation process is simple and easy to implement, strong in operability, stable in process, and is capable of improving the bioavailability and curative effect of the medicine.
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