Taxane drug albumin nanoparticle freeze-drying preparation for injection and preparation method

The invention discloses a taxane drug albumin nanoparticle freeze-drying preparation for injection and a preparation method. According to the invention, based on physical factors, albumin is heated to a certain temperature to expand the spatial structure of albumin, and then is uniformly mixed with taxane drugs, and then the mixture is quickly cooled through physical factors; the taxane drug is coated or adsorbed to the inside or the surface of the albumin, so as to prepare the soluble taxane drug albumin nanoparticle preparation. During the preparation of the soluble taxane drug albumin nanoparticle preparation, toxic chemical crosslinking agents are not added, so that the prepared soluble taxane drug albumin nanoparticle preparation can reduce the stimulation to vessels of patients during injection and weaken the pain of patients during the use; besides, damage to the organism, caused by toxic residues released by the cross-linking agents in vivo is avoided; according to the invention, more and more taxane drugs are passively accumulated at tumor tissues in a targeting manner, so that the safety and stability of the taxane drug are improved, the action time of the drug is prolonged, and toxic and side effects of the drug are weakened.