Effects of commercial pancreozymin preparation (Cecekin) and gastrin pentapeptide upon acid and pepsin secretion in gastric fistula dogs

Abstract This study compared the stimulatory effects of pancreozymin-cholecystokinin (Cecekin) and gastrin pentapeptide upon gastric secretion and confirmed that small doses of pancreozymin stimulated both acid and pepsin secretion from gastric fistula dogs. Acid output with pancreozymin was about one-third of that in response to pentapeptide, but this difference was narrowed by the addition of a small dose of methacholine. Pepsin secretion was equally stimulated by both drugs. The differences between the effects of the two drugs may be due to an antral inhibitory mechanism; contaminants of the commercial pancreozymin preparation were probably insufficient to account for these differences.