Effects of 5-HT receptor on isoflurane-and sevoflurane-induced amnesia in mice

Objective To investigate the relationship between 5-hydroxytry ptamine(5-HT) receptor and the amnesia induced by isoflurane and sevoflurane in mice. Methods Animal models were established by intraperitoneal injection of isoflurane (0.3 ml/ kg) and sevoflurane (3 ml/kg). After intracerebroventricular injection (icv) of different doses of WAY100635, 5-HT receptor antagonist, step down latency (SDL), error times in step down test and step through latency (STL), error times in step through test were observed and recorded. Results Intracerebroventricular injection of WAY 100635 might extend SDL and STL, and reduced error times of isoflurane-and sevoflurane-induced memory impairment in mice. Conclusion 5-HT receptor involves in isoflurane-and sevoflurane-induced amnesia. Key words: 5-HT receptor;  Amnesia;  Step down task;  Step through task;  WAY 100635