Synthesis and hemostatic and antimicrobial activities of the sodium salts of N-acyl-5-bromo(3,5-dibromo)anthranilic acids
2011
Acylation of 5-bromo(3,5-dibromo)anthranilic acids with the corresponding anhydrides yielded 10 N-acyl-5-bromo(3,5-dibromo)anthranilic acids. The resulting compounds were reacted with 10% sodium hydroxide to convert them to the corresponding sodium salts. The hemostatic and antimicrobial activities against Staphylococcus aureus and Escherichia coli of the resulting compounds were studied. Compound IV, containing a phenyl residue in the acyl fragment, was found to have marked hemostatic activity (18.2%) and weak antimicrobial activity. The minimum inhibitory concentration for this compound was 500 μg/ml against S. aureus and E. coli. The other sodium salts were significantly less active.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
1
Citations
NaN
KQI