Effects of atrial septum pacing on atrial fibrillation and heart function in patients with sick sinus syndrome

Objective To investigate the effect of atrial septum pacing on atrial fibrillation and heart function on patients with sick sinus syndrome compared with traditional dual-chamber pacemaker. Methods A total of 60 patients were enrolled into study group and control group. All patients received dual-chamber pacemaker. The active fixation pacing atrial lead was implanted in atrial septum in study group, the patients in control group received traditional dual-chamber pacemaker. The indexes about left ventricular remodeling and cardiac function were mea-sured by Doppler echocardiography and N-terminal pro brain natriuretic peptide level by Chemiluminescence Deter-mination respectively on the 3rd, 6th, 9th, 12th months. Results In one year follow-up after atrial septal pace-maker implanted, paroxysmal atrial fibrillation (PAF) disappeared or decreased in 20 patients (71.4%) in study group compared with that in control group (P<0.05). PAF duration, LAD, LVDd and N-terminal pro brain natriuretic peptide significantly reduced in the one year follow-up (78.8±6.9)min VS(106.7±12.8)min, (36.2±4.8)mm VS(41.7±6. 1)mm, and(49.8±6.1)mm VS(66.5±4.2)mm, (330.8±30.5)pg/ml VS(502.8±21.4)pg/ml. Conclusion Atrial septal pacing have a p preventive and therapeutic effect on PAF, left ventricular remodeling and heart function in patients with sick sinus syndrome. Key words: Sick sinus syndrome; Paroxysmal Atrial Fibrillation;  Echocardiography; Atrial Septal Pacing;  N-terminal probrain natriuretic peptide