Efficacy and tolerability of prostaglandin–timolol fixed combinations: an updated systematic review and meta-analysis

AbstractBackground:Prostaglandin–timolol fixed combinations (PG–timolol FCs) are now widely used to reduce intraocular pressure in patients with glaucoma. The efficacy and tolerability of these drugs are worthy of further exploration. An updated systematic review and meta-analysis was performed to assess the clinical efficacy and tolerability of the three PG–timolol FCs.Methods:Pertinent randomized, controlled trials were identified through systematic searches of PubMed, Embase, the Cochrane central register of controlled trials and the Chinese Biomedicine Database. The main efficacy measures were the weighted mean differences (WMDs) for the reduction from baseline to end of treatment in IOP at 9 am, 12 pm and 4 pm and diurnal curve. The main tolerability measures were the odds ratios (ORs) for the incidence of conjunctival hyperemia.Results:Nine studies involving 991 patients were included in the meta-analysis. Latanoprost–timolol FC (LTFC) and travoprost–timolol FC (TTFC) were not significantly differen...