Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

An RNAi screen of protein phosphatases identifies PP2A–B55α as the main mitotic exit phosphatase in human cells. After mitosis, PP2A–B55α depletion delays the reassembly of the nuclear envelope and Golgi and the decondensation of chromatin.