Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives
2005
Abstract Twenty-five N -demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC–MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N -demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis .
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