Image-based risk score to predict recurrence of ER+ breast cancer in ECOG-ACRIN Cancer Research Group E2197.

540Background: Tumor grade is a predictor of breast cancer recurrence, independent of gene expression assays such as Oncotype Dx (ODx). However, grade suffers from significant intra- and inter-observer variability, limiting its clinical utility. Advances in whole slide imaging facilitate computerized analysis of HE patients had 0-3 positive axillary nodes and HE 60 patients suffered recurrence. A subset of 124 patients (27 recurrences) were HER2-. Another (enriched) subset (116 patients with 27 recurrences) had accompanying ODx scores. To establish IbRiS low- and high-risk groups, we determined (over the 378 patients) a cutoff such that ...