Opposite changes in cerebellar vs. cortical blood brain barrier (BBB) expression in aged and hydrocephalic rats

Background Little is known about the cerebellum in NPH. Studies show that neurotransmitter changes in the cerebellum are opposite to the cortex [1,2]. In Kaolin-induced hydrocephalus, increases of A-beta peptides at cortical and hippocampal microvessels were found [3]. Reciprocal changes in BBB receptors, LRP-1, which transports A-beta out of, and RAGE, which transports A-beta into the brain, indicated a defective clearance might be causal. We looked at LRP-1 and RAGE expression changes in the cerebellum vs. the cortex in hydrocephalic and aged rats.