Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers.

N-acetylaspartylglutamate prevents the denervation-induced increase in the volume of muscle fibers in rat diaphragm, the phenomenon being more pronounced for the hydrolysable isomer. The effect of dipeptide manifested against the background of blockade of metabotropic glutamate receptors. It was hypothesized that N-acetylaspartylglutamate is involved in the regulation of the volume of skeletal muscle fibers via activation of ionotropic receptors by both dipeptide and glutamate molecules.