A Role for Cellular Prion Protein in Late-Onset Alzheimer's Disease: Evidence from Preclinical Studies

Alzheimer's disease (AD), the most prevalent form of dementia, affects 1 in 9 individuals >65 years old ([Alzheimer's Association, 2016][1]). Cognitive decline is the most distinctive symptom of AD, and it strongly correlates with synapse loss ([Masliah et al., 1990][2]; [Terry et al., 1991][3]).