Leukaemogenic and mutagenic activity of the butyrophenon, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone (haloperidol)

: Development of mainly monocytic-myeloid leukaemias was observed in two strains of mice upon i.p. administration of 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone (haloperidol), an antipsychotic drug. Haloperidol was also shown to be mutagenic in the Ames Salmonella test system.