Application of transperineal prostate projection supersaturated needle in prostate biopsy

Objective To explore diagnostic value of transperineal prostate projection supersaturated needle (TPPSN) after initial negative biopsy result and to assess the efficacy and safety. Methods A total of 218 patients were enrolled in this study. These patients were diagnosed with benign prostatic hyperplasia by transperineal template biopsy but were suspected to have prostate cancer through the abnormal prostate specific antigen(PSA) and digital rectal examination (DRE). All patients were divided into the observation group (TPPSN) and the control group (traditional transperineal template saturated biopsies) according to different way of puncture. According to the prostate volume different interval ( 80 mL), the positive rates of two groups were contrasted. The incidence of postoperative complications such as gross hematuria, fever, retention of urine and perineum discomfort of two groups were compared. Results The total cancer detection rate of the observation group was higher than that of the control group (P=0.044), the improvement of cancer detection rate was higher only when the prostate volume was greater than 80 mL (P=0.041). Compared to the control group, the incidence of complication such as gross hematuria, fever, retention of urine and perineum discomfort by TPPSN was low, but there was no significant difference (P>0.05 ). Conclusions For the patients who are initial negative biopsy but highly suspected with prostate cancer, the TPPSN can improve the positive rate of prostate biopsy. It can more accurate positioning the prostate cancer and is a safe and effective diagnostic method for prostate cancer. TPPSN can be a safe and reliable way to prostate biopsy. Key words: Prostate; Biopsy, Needle; Perineum