Effect of Valinomycin-Induced Potassium Influx on the Formation of Reactive Oxygen Species in the Rat Brain Mitochondria
2013
We studied the effect of valinomycin-induced voltage-dependent potassium influx on the formation of reactive oxygen species (ROs) in preparations of isolated rat brain mitochondria. In the presence of valinomycin, the stationary rate of formation of ROSs decreased with increase in the K+ concentration in the medium. We conclude that the drop in ROS production in the brain mitochondria is due to the depolarizing effect of voltage-dependent K+ influx. Our experiments show that the mechanism underlying the control of ROS formation in the brain mitochondria under conditions of potassiuminduced valinomycin-related depolarization of the membrane is voltage-dependent.
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