Well-Defined Biomimicking Brush-Polymer Self-Assemblies Revealing Cholesterol- and Phosphorylcholine-Enriched Surface
2017
We have newly synthesized a series of well-defined brush polyethers bearing cholesterol (Chol) and phosphorylcholine (PC) moieties in various compositions which can mimic cell membrane. They were thermally stable up to at least 230 °C and soluble in common solvents, showing good solution processability. Excitingly, they all favorably self-assembled, forming multibilayer structures with 21 chain conformation; in comparison, the brush polyether bearing only PC-bristles formed orthorhombically packed cylinder (OPC) structure with 125 helical chain conformation. Such multibilayer structure formations could be driven by a strong self-assembling ability of the Chol-bristle in extended conformation; the multibilayer structure formation was further promoted by the presence of PC-bristles. The OPC structure formation could be driven by a lateral packing ability of the brush polymer chain in the helical confirmation resulted from the minimization of repulsive interactions in the neighbored zwitterionic PC-bristles....
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
15
References
5
Citations
NaN
KQI