Peptides inducing psychosis

Abstract TRH and MIF analogues pyroglutamyl-N γ [2-(3′, 4′-dihydroxyphenyl)-2-hydroxyethylglutaminyl-prolinamide ( 1 ) and prolyl-N γ [2-(3′, 4′-dihydroxyphenyl)-2-hydroxyethyl]glutaminyl-glycinamide ( 2 ) were synthesized. Prolonged effects on higher nervous activity and behavioral effects in cats were caused by peptides 1 and 2 after intraperitoneal injection.