Research paper EFFECTS OF TRANEXAMIC ACID AND ITS DERIVATIVES ON THE CHEMICAL AND METABOLIC MODULATION OF GLUTATHIONE IN

PURPOSE The aim of the present study was to examine the effects of Tranexamic acid and its derivatives, more specifically N-Acetyl-tranexamic acid on the metabolism and chemical modulation of Glutathione (GSH) in the aqueous solutions. METHOD All the solutions were prepared in phosphate buffer solution pH 7.62 and absorbances were measured at 412 nm using U.V/ Visible spectroscopy. RESULTS It was found that N-Acetyl-tranexamic acid had a marked effect on lowering of GSH and/or thiols in aqueous solutions as compared to the effect of Tranexamic acid and N-Phthaloyl-tranexamic acid. CONCLUSIONS Finding provide evidence that N-Acetyl-tranexamic acid causes the depletion of GSH and/or thiols in aqueous solutions due to the oxidation.