Use of liposomes as carriers for immunomodulatory polypeptides: Studies on thymostimulin encapsulation and retention

Abstract The incorporation of thymostimulin, an immunoactive hormone extracted from calf thymus, into liposomes was characterized by means of DSC analysis. Changes in vesicle composition, as well as in the presence of cholesterol, led to variations in thermotropic behaviour and influenced their incorporation efficiency and stability. Among the prepared formulations, liposomes prepared using equimolar amounts of DPPC and DMPC showed the highest value (80%) for drug incorporation.