Chapter 11:Co-crystal Solubility and Thermodynamic Stability

Co-crystals play a significant role in solving bioavailability problems because they have the ability to fine tune solubility and delivery of drugs. Understanding the link between the structure/composition of co-crystals and their solution properties is important, so that co-crystal and formulation conditions can be selected on a rational basis. This chapter presents the thermodynamic factors that influence co-crystal solubility, the parameters that determine co-crystal stability, and experimental methods that overcome the difficulties of co-crystal conversion to less soluble phases.