Synthetic Studies on Maitotoxin. 1. Stereoselective Synthesis of the C′D′E′F′-Ring System Having a Side Chain

The stereoselective synthesis of the maitotoxin C′D′E′F′-ring system having a side chain has been accomplished through a convergent strategy. The key reactions include Horner-Wadsworth-Emmons coupling of the C′D′E′-ring and the side chain and subsequent construction of the F′-ring by silane reduction of dihydropyran.