Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents
2017
Andrographis paniculata (A. paniculata) is a medicinal plant used in the Indian and Chinese
traditional medicinal systems for its various beneficial properties of therapeutics. This is due to
the presence of a diterpene lactone called ‘andrographolide’. Several biological activities like antiinflammatory,
antitumour, anti-hyperglycaemic, anti-fertility, antiviral, cardio protective and hepatoprotective
properties are attributed to andrographolide and its natural analogs. The studies have
shown that not only this diterpene lactone (andrographolide), but also other related terpenoid analogs
from A. paniculata could be exploited for disease prevention due to their structural similarity with diverse
pharmacological activities. Several scientific groups are trying to unveil the underlying mechanisms
involved in these biological actions brough aout by andrographolide and its analogs. This review
aims at giving an overview on the therapeutical and/or pharmacological activities of andrographolide
and its derivatives and also exemplify the underlying mechanisms involved.
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