A Multi‐Center Analysis of the Use of Enalapril and Lisinopril in Elderly Hypertensive Patients
1994
OBJECTIVE: To evaluate the clinical use and adverse effects of enalapril and lisinopril in elderly hypertensive subjects.
DESIGN: A multi-center, retrospective, drug use evaluation survey.
SETTING: Ambulatory care clinics at 14 VA and 14 academic medical centers.
PATIENTS: 422 elderly (>60 years of age) patients with hypertension and no clinical evidence of congestive heart failure.
INTERVENTION: At least 3 consecutive months of anti-hypertensive therapy with either enalapril or lisinopril.
MEASUREMENTS: Blood pressure, serum creatinine, serum potassium, concomitant disease states, concurrent medications, and documentation of any adverse event that might be related to ACE inhibitor therapy.
RESULTS: There were no significant differences in systolic and diastolic blood pressures, serum creatinine, or serum potassium between enalapril- and lisinopril-treated patients at baseline and after 3 months of therapy. Both treatments resulted in a significant reduction in diastolic blood pressure. There was no significant difference in the incidence of adverse effects between the two treatments. Significantly more patients were dosed on a twice daily regimen of enalapril than lisinopril.
CONCLUSION: The data from this retrospective study confirm the safe and effective use of enalapril and lisinopril, two long-acting ACE inhibitors, in elderly hypertensive patients.
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