Successful treatment of Acinetobacter meningitis with meropenem and rifampicin

in a rat model of pneumonia. This supports these results and suggests that the combination of aztreonam and fosfomycin is a potential combination regimen effective against MBL-producing Gram-negative bacteria. However, this report also strengthens the fact that detection of MBL production among Gram-negative bacilli is crucial for the optimal treatment of patients and to control the spread of resistance. It also confirms that VIM-2 is by far the most common VIM-type b-lactamase. This isolate was the first and unique P. aeruginosa harbouring this resistance phenotype in our hospital. Moreover, even if this prostatitis corresponded to a nosocomial infection acquired in our hospital, we could not exclude the fact that this patient coming from Saudi Arabia was previously colonized with this strain which was selected by extendedspectrum cephalosporins. To our knowledge, this observation could therefore constitute the first report of the dissemination of VIM-MBL in the Middle East.