Microfluidic Blood Filtration Device
2011
Rapid decentralized biomedical diagnostics have
become increasingly necessary in a medical environment of
growing costs and mounting demands on healthcare
personnel and infrastructure. Such diagnostics require
low-cost novel devices that can operate at bedside or in
doctor offices using small amounts of sample that can be
extracted and processed on the spot. Thus, point-of-care
sample preparation is an important component of the
necessary diagnostic paradigm shift. We therefore introduce
a microfluidic device which produces plasma from whole
blood. The device is inexpensive, reliable, easy to fabricate,
and requires only 3.5 kPa pressure to operate. The device is
fully compatible with microfluidic diagnostic chips. The
output 23-gauge microtube of the former can be directly
plugged into the input ports of the latter allowing
immediate applicability in practice as a sample-prep prestage
to a variety of emergent microfluidic diagnostic
devices. In addition, the shown approach of filter encapsulation
in elastomer has principle importance as it is
compatible with and applicable to microfluidic sampleprep
integration with analytical stages within the same
elastomeric chip. This can eventually lead to finger-prick
blood tests in point-of-care settings.
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