Лимфоидное микроокружение при хроническом лимфоцитарном лейкозе

Apart from studies devoted to the relationship of bone marrow stroma and hematopoiesis, more and more researchers attention attracts stromal-parenchymal interactions in lymph nodes, where the final stages of B-lymphopoesis and immunogenesis occur. Study of cell populations lymph nodes of patients with lymphoprolypherative diseases revealed that along with changes in lymphoid cells, the abnormalities in morphological and functional properties of stromal elements of lymphoid microenvironment took place. However there practically no information about morphological peculiarities of the stromal microenvironment of lymphoid tissue of patients with malignant lymphoid cells proliferation in the lymph nodes. Stroma of lymph nodes of 57 patients with newly diagnosed CLL with emphasis on the state of follicular dendritic cells and microcirculatory bed was studied. The changes of stromal microenvironment were set, namely disintegration of follicular dendritic cells and decrease in their number, as well as reinforced angiogenesis.