Testing the amyloid hypothesis of Alzheimer's disease in vivo
2010
In this issue of The Lancet Neurology , Rinne and colleagues report something of a breakthrough by demonstrating the feasibility of eventually testing the so-called amyloid hypothesis of sporadic Alzheimer's disease in vivo. According to their analysis, a passive immunotherapy protocol with an anti-amyloid-β monoclonal antibody (bapineuzumab) was associated with a decrease in the cerebral PET signal after administration of the amyloid plaque imaging compound carbon-11-labelled Pittsburgh compound ...
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