Aminomethylpiperidine derivatives, and preparation method and pharmaceutical application thereof

The invention belongs to the field of pharmacy, and relates to aminomethylpiperidine derivatives as shown in a general formula (I) or salts thereof, and a preparation method for the aminomethylpiperidine derivatives and application of the aminomethylpiperidine derivatives in preparation of drugs used for treating opioid receptor mediated diseases. The aminomethylpiperidine derivatives provided by the invention show affinity activity and agonistic or antagonistic functional activity to mu and delta opioid receptors in an in-vitro experiment, and show analgesic activity with moderate intensity in an animal in-vivo experiment. The aminomethylpiperidine derivatives provided by the invention can be used for preparing the drugs used for treating the opioid receptor mediated diseases, wherein the diseases comprise but are not limited to pains, gastrointestinal diseases, depressive disorders, pruritus, addiction, etc.; and the aminomethylpiperidine derivatives have significant potential clinical application values in treatment of pains.