EFFECT OF THYROID HORMONE ON BONE AND MINERAL METABOLISM IN RAT : EVALUATION BY BIOCHEMICAL MARKERS

We evaluated the effects of the thyroid hormone on bone and mineral metabolism in rats using biochemical markers {pyridinoline (Pyr), deoxypyridinoline (Dpyr), Osteocalcin (OC), alkaline phosphatase (Alp)] and the measuring of bone mineral density (BMD). First, the rats were divided into three groups: 1)control group 2)The fifty μg group (T3-50) [It was given 50 μg/kg/ip/day of triiod-1-thyronine (T3) for 2 weeks.] 3)The hundred μg group (T3-100) [It was given 100 μg/kg ip/day of T3 for 2 weeks.] Next, the rats were divided into two groups: 1)control group and 2)T3 group. The latter was given 100 μg/kg of T3 ip/day for 4 weeks. In experiment 1, Pyr and Dpyr levels in the T3 groups were significantly higher or well tended to be higher than those in the control group. OC levels in the T3 groups were significantly higher than in the control group until day 7. The Z-score of Pyr and Dpyr in T3–100 were two to thirteen times higher than those of OC and Alp. In experiment 2, Pyr and Dpyr levels in the T3 group ...