The Antitumor Nanovaccination Under Magnetic Field Control

The present paper aims to develop an antitumor nanovaccine with magnetosensitive properties. The article describes the ability to manipulate the immune response and improve targeted delivery of the antitumor nanovaccine based on magnetic nanoparticles incapsulated inside dendritic cells under the influence of an external magnetic field. The magnetic field influence upon nanovaccine migration to regional lymph nodes and distribution has been analyzed. The conducted experiments showed up to 14% greater antitumor effect of nanovaccine under magnetic field control compared to the known methods for vaccination.