Spiroindoles as Potential Pharmacophores
2017
The spiroindole heterocyclic scaffold is found in many natural
products and has been identified as an important bioactive agent. Over the
past few decades, various spiroindole-containing compounds have been
reported to possess biological properties and hence found in the structure
of many synthetic pharmaceuticals. This mini-review describes the most
promising examples of this class of compounds possessing biological activity
including anticancer, anti-inflammatory, and antimicrobial activities. To
the best of our knowledge, the earlier reviews did not cover the
pharmaceutical properties of synthetic and naturally occurring spiroindoles;
thus, the current review focuses on the biological activity of compounds
containing the spiroindole scaffold.
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